Objective The purpose of this study is to investigate the status and influencing factors of financial toxicity（FT） in patients with prostate cancer,and to provide a basic theory for reducing FT levels in prostate cancer patients. Methods With the convenience sampling method,a total of 281 prostate cancer patients were recruited from a hospital in Shanghai from January 2020 to August 2021. A cross-sectional study was conducted by the general data questionnaire,the Comprehensive Scores for Financial Toxicity based on the Patient-Reported Outcome Measures（COST-PROM）,the Medical Coping Modes Questionnaire（MCMQ） and the General Self-Efficacy Scale（GSES）. Besides,multiple linear regression was used to identify predictors of FT in patients with prostate cancer. Results The total score of COST-PROM was 22.0 （17.0,24.0）. Multiple linear regression analysis showed that the factors of the diagnosis of prostate cancer affecting the retirement age,the average income per person in family,the treatment cost in the last 3 months,the dimension of surrender in medical coping style and the level of self-efficacy were the main influencing factors of FT（P<0.001）,which accounted for 45.6% of total variation. Conclusion The FT of patients with prostate cancer is in the middle and low level. Clinical staff should use the effective intervention measures to help patients go back to work,estimate their economic conditions for choosing individualized treatment,help them seek more social supports and resources,and guide them to manage problems in positive ways and enhance the level of self-efficacy,in order to reduce the level of FT and improve the quality of their life.